Specific Patterns of Molecular Mutations Determine the Morphologic Differentiation Stages in Acute Myeloid Leukemia (AML)
نویسندگان
چکیده
منابع مشابه
acute myeloid leukemia (aml): the role of intensive induction chemotherapy
intensive induction therapy-in acute myeloid leukemia (aml), as in some other systemic malignancies- is a strategy fundamentally different from post-remission strategies. approaches like consolidation treatment, prolonged mainte nance, and autologous or allogeneic transplantation in the first remission are directed against minimal residual disease with a malignant cell population having survive...
متن کاملEvaluation of the CD123 Expression and FLT3 Gene Mutations in Patients with Acute Myeloid Leukemia
Background and Objective: Identification of cytogenetic and molecular changes plays an important role in acute myeloid leukemia (AML) patients. Thus, they are used in classification, prognosis and treatment of the disease. The CD123 expression and FLT3 gene mutations are also the variations that may assist in prognosis and treatment of patients with AML.Methods:</...
متن کاملDetection of R882 Mutations in DNMT3A Gene in Acute Myeloid Leukemia: A Method Comparison Study
Background: Somatic mutations in the hotspot region of the DNA-methyltransferase 3A (DNMT3A) gene were recurrently identified in acute myeloid leukemia (AML). It is believed that DNMT3A mutations confer an adverse prognosis for AML patients. These lines of evidence support the need for a rapid and cost-efficient method for the detection of these mutations. The present study aimed to establish h...
متن کاملChromosomal rearrangements in acute myeloid leukemia (AML)
E Belloni, M Trubia, P Gasparini, C Micucci, C Tapinassi, S Confalonieri, P Nuciforo, B Martino, F Lo-Coco, PP Di Fiore and PG Pelicci Istituto Europeo di Oncologia, Milan, Italy Campus IFOM-IEO, Milan, Italy Divisione di Ematologia, Azienda Ospedaliera Bianchi-Malacrino-Morelli, Reggio Calabria, Italy Università di Roma Tor Vergata, Department of Biopatologia e Diagnostica per Immagini, Rome, ...
متن کاملMolecular pathway activation features of pediatric acute myeloid leukemia (AML) and acute lymphoblast leukemia (ALL) cells
Acute lymphoblast leukemia (ALL) is characterized by overproduction of immature white blood cells in the bone marrow. ALL is most common in the childhood and has high (>80%) cure rate. In contrast, acute myeloid leukemia (AML) has far greater mortality rate than the ALL and is most commonly affecting older adults. However, AML is a leading cause of childhood cancer mortality. In this study, we ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Blood
سال: 2014
ISSN: 0006-4971,1528-0020
DOI: 10.1182/blood.v124.21.2388.2388